Movement Disorder Evaluation

Important

This report is intended to assist qualified Health Care Profesionals (HCP) in the assessment of an individual referred under the suspicion of having Parkinson’s Disease.

Clinical Context

This report presents several AI metrics derived from objective measures from individuals performing a battery of test using Manus Neurodynamica NeuroMotor PenTM.

These presented metrics combine factors from detailed measurement recordings made whilst the individual performs a battery of well established neurological test tasks.

The metrics have been assessed in a UK reference population and an individual’s results are presented in this clinical context. The HCP should review Clinical,Reference, Study et al [1] to establish applicability and limitations.

The information in this report should be used in the context of a full neurological assessment conducted to the current standard of care practices to establish a diagnosis.

Subject and Recording Details

Subject ID NMC049
Sex MALE
Dominant hand LEFT
Test administered by neuromedic@manusdevices.net
Test date and time 2022-10-04 09:33
Test battery Circle, Spiral, Elel, FITTS Short Modified, FITTS Long Modified, ZigZag, ZigZag Offset
Operator comment OLD PATIENT TBL MADOPAR 250MG 3X1\4

Overall Assessment

PD

Subject performance similar to PD population (recommend review of report details)

Clinical context

In the clinical reference population, 29 individuals with a value less than 0.62 were subsequently diagnosed with PD. That is, 69.05% of the PD diagnoses in the study.

Additionally, 0 individuals with a value greater or equal to 0.62 were subsequently diagnosed as non PD. That is, 0.0% of the non PD diagnoses in the study.

Symptom Scores

These mini boxplots show the scores in a clinical context. Currently against the ‘Walker study’ data. A bigger pool would be much better (so max 83 individuals, usually lower if raw data did not result in successful classification).

The scores are ‘relative to the PD cohort’ and this is how they should be interpreted. A consequence of this is that a low tremor score below may actually correspond to obvious tremor in the raw data, and vice versa.

Micrographia

The micrographia symptom assessment is derived from a combination of factors in the elel task.

{'FN': 25, 'TN': 21, 'TP': 17, 'FP': 9}

Tremor

The tremor score is a combination of features in the circle, spiral and both zizag tasks.

{'FN': 17, 'TN': 12, 'TP': 25, 'FP': 18}

Bradykinesia

The bradykinesia score is a combination of features in the circle, spiral, both zizag and elel tasks.

{'FN': 33, 'TN': 28, 'TP': 9, 'FP': 2}

Spatial Accuracy

The accuracy score is a combination of factors in the spiral, both zigzags and both Fitts tasks.

{'FN': 20, 'TN': 15, 'TP': 22, 'FP': 15}

Test Battery Details

Circle

numCircles 10
timePerCircleMean 8.184
timePerCircleCoV 0.180616
timePerCircleSlope -0.0506532
meanError 4.49373
tremorFreq 5.76172
tremorRelPower 33.2826
tremorGyroAmpMean 0.0214046
tremorGyroAmpSlope 0.00506534
tremorGyroAmpCoV 0.378477
tremorCoordAmpMean 0.176947
tremorCoordAmpSlope 0.00597265
tremorCoordAmpCoV 0.836653
tremorAccAmpMean 0.0899135
tremorAccAmpSlope 0.000980931
tremorAccAmpCoV 0.0775647
tremorPcRelVar 0.610877
tremorPcX -0.99233
tremorPcY -0.12362

Circle Segment 1

Duration 10.04 s, Accuracy Estimate 3.057 (lower is better)

Circle Segment 2

Duration 9.68 s, Accuracy Estimate 3.068 (lower is better)

Circle Segment 3

Duration 8.52 s, Accuracy Estimate 3.853 (lower is better)

Circle Segment 4

Duration 9.24 s, Accuracy Estimate 5.377 (lower is better)

Circle Segment 5

Duration 9.48 s, Accuracy Estimate 3.989 (lower is better)

Circle Segment 6

Duration 7.48 s, Accuracy Estimate 5.783 (lower is better)

Circle Segment 7

Duration 8.12 s, Accuracy Estimate 3.679 (lower is better)

Circle Segment 8

Duration 6.0 s, Accuracy Estimate 5.618 (lower is better)

Circle Segment 9

Duration 5.92 s, Accuracy Estimate 4.977 (lower is better)

Circle Segment 10

Duration 7.36 s, Accuracy Estimate 5.538 (lower is better)

Spiral

numSpirals 9
timePerSpiralMean 18.6533
timePerSpiralCoV 0.184355
timePerSpiralSlope 0.00957827
meanError 3.33358
tremorFreq 5.46875
tremorRelPower 35.4553
tremorGyroAmpMean 0.0287649
tremorGyroAmpSlope -5.49104e-05
tremorGyroAmpCoV 0.499939
tremorCoordAmpMean 0.284754
tremorCoordAmpSlope -0.00106728
tremorCoordAmpCoV 0.833449
tremorAccAmpMean 0.0388492
tremorAccAmpSlope -1.91624e-05
tremorAccAmpCoV 0.37346
tremorPcRelVar 0.552081
tremorPcX 0.954282
tremorPcY -0.298908

Spiral Segment 1

Duration 19.24 s, Accuracy Estimate 3.049 (lower is better)

Spiral Segment 2

Duration 19.16 s, Accuracy Estimate 2.742 (lower is better)

Spiral Segment 3

Duration 14.0 s, Accuracy Estimate 3.648 (lower is better)

Spiral Segment 4

Duration 19.0 s, Accuracy Estimate 4.354 (lower is better)

Spiral Segment 5

Duration 15.64 s, Accuracy Estimate 2.731 (lower is better)

Spiral Segment 6

Duration 24.48 s, Accuracy Estimate 3.967 (lower is better)

Spiral Segment 7

Duration 17.32 s, Accuracy Estimate 3.95 (lower is better)

Spiral Segment 8

Duration 23.12 s, Accuracy Estimate 2.672 (lower is better)

Spiral Segment 9

Duration 15.92 s, Accuracy Estimate 2.889 (lower is better)

Elel

eDurationMean 0.604333
eDurationStd 0.308237
eDurationStdnorm 0.510044
eDurationMedian 0.4875
eDurationQuartdelta 0.21
eDurationQuartdeltanorm 0.430769
eDurationKurt 7.37191
eDurationTrenddiff -0.085
eDurationTrendratio 0.842593
eWidthMean 3.6465
eWidthStd 1.62588
eWidthStdnorm 0.445873
eWidthMedian 3.042
eWidthQuartdelta 2.457
eWidthQuartdeltanorm 0.807692
eWidthKurt 3.15824
eWidthTrenddiff -1.638
eWidthTrendratio 0.631579
eHeightMean 8.3889
eHeightStd 3.348
eHeightStdnorm 0.399098
eHeightMedian 7.839
eHeightQuartdelta 2.34
eHeightQuartdeltanorm 0.298507
eHeightKurt 4.76597
eHeightTrenddiff -0.702
eHeightTrendratio 0.913043
eAspectMean 0.442722
eAspectStd 0.129142
eAspectStdnorm 0.291699
eAspectMedian 0.433724
eAspectQuartdelta 0.18227
eAspectQuartdeltanorm 0.420244
eAspectKurt 2.17655
eAspectTrenddiff -0.0432203
eAspectTrendratio 0.903955
eSlantMean -0.130514
eSlantStd 0.199588
eSlantStdnorm -1.52924
eSlantMedian -0.147208
eSlantQuartdelta 0.240291
eSlantQuartdeltanorm -1.63233
eSlantKurt 2.8658
eSlantTrenddiff -0.00409244
eRtopMean 0.674185
eRtopStd 0.187513
eRtopStdnorm 0.278133
eRtopMedian 0.62381
eRtopQuartdelta 0.262626
eRtopQuartdeltanorm 0.421004
eRtopKurt 2.53659
eRtopTrenddiff 0.0142857
eRbotMean 1.05379
eRbotStd 0.451415
eRbotStdnorm 0.428371
eRbotMedian 0.983871
eRbotQuartdelta 0.533333
eRbotQuartdeltanorm 0.542077
eRbotKurt 2.95841
eRbotTrenddiff -0.0322581
eRrightMean 0.809394
eRrightStd 0.150994
eRrightStdnorm 0.186552
eRrightMedian 0.834475
eRrightQuartdelta 0.127186
eRrightQuartdeltanorm 0.152414
eRrightKurt 7.61808
eRrightTrenddiff 0.0469697
eRleftMean 0.464154
eRleftStd 0.124389
eRleftStdnorm 0.267992
eRleftMedian 0.48188
eRleftQuartdelta 0.160969
eRleftQuartdeltanorm 0.334045
eRleftKurt 2.71732
eRleftTrenddiff 0.0671316
lDurationMean 1.20821
lDurationStd 0.556937
lDurationStdnorm 0.460962
lDurationMedian 0.98
lDurationQuartdelta 0.64125
lDurationQuartdeltanorm 0.654337
lDurationKurt 4.71145
lDurationTrenddiff -0.43
lDurationTrendratio 0.660079
lWidthMean 6.447
lWidthStd 2.01022
lWidthStdnorm 0.311807
lWidthMedian 6.435
lWidthQuartdelta 2.01825
lWidthQuartdeltanorm 0.313636
lWidthKurt 6.11861
lWidthTrenddiff -0.702
lWidthTrendratio 0.890909
lHeightMean 27.063
lHeightStd 5.38569
lHeightStdnorm 0.199006
lHeightMedian 26.325
lHeightQuartdelta 3.83175
lHeightQuartdeltanorm 0.145556
lHeightKurt 5.08285
lHeightTrenddiff -0.936
lHeightTrendratio 0.965368
lAspectMean 0.237913
lAspectStd 0.050313
lAspectStdnorm 0.211476
lAspectMedian 0.235849
lAspectQuartdelta 0.0649492
lAspectQuartdeltanorm 0.275385
lAspectKurt 3.97421
lAspectTrenddiff -0.00821018
lAspectTrendratio 0.965517
lSlantMean -0.106336
lSlantStd 0.120425
lSlantStdnorm -1.1325
lSlantMedian -0.0784314
lSlantQuartdelta 0.13746
lSlantQuartdeltanorm -1.75262
lSlantKurt 3.56864
lSlantTrenddiff 0.105259
lRtopMean 0.518367
lRtopStd 0.171694
lRtopStdnorm 0.331221
lRtopMedian 0.532258
lRtopQuartdelta 0.231909
lRtopQuartdeltanorm 0.435708
lRtopKurt 2.37633
lRtopTrenddiff 0.204082
lRbotMean 0.977252
lRbotStd 0.373108
lRbotStdnorm 0.381793
lRbotMedian 0.893617
lRbotQuartdelta 0.631518
lRbotQuartdeltanorm 0.706698
lRbotKurt 2.30463
lRbotTrenddiff -0.283333
lRrightMean 0.677314
lRrightStd 0.145156
lRrightStdnorm 0.214311
lRrightMedian 0.683908
lRrightQuartdelta 0.144967
lRrightQuartdeltanorm 0.211969
lRrightKurt 2.74811
lRrightTrenddiff 0.127432
lRleftMean 0.560448
lRleftStd 0.231783
lRleftStdnorm 0.413567
lRleftMedian 0.529412
lRleftQuartdelta 0.396329
lRleftQuartdeltanorm 0.748621
lRleftKurt 1.58933
lRleftTrenddiff -0.361503

Elel Segment 1

Elel Segment 2

Elel Segment 3

Elel Segment 4

Elel Segment 5

Elel Segment 6

Elel Segment 7

Elel Segment 8

Elel Segment 9

Elel Segment 10

Elel Segment 11

Elel Segment 12

Elel Segment 13

Elel Segment 14

FITTS Short Modified

meanTouchScore 0.494026
sumTouchScores 10.3745
meanMovementTime 0.86175
numTouches 21
undershootPercentage 4.7619
overshootPercentage 42.8571

fitts_short data not in signals file.

FITTS Long Modified

meanTouchScore 0.858747
sumTouchScores 12.8812
meanMovementTime 1.275
numTouches 15
undershootPercentage 6.66667
overshootPercentage 13.3333

fitts_long data not in signals file.

ZigZag

numZigzags 6
timePerZigzagMean 25.4133
timePerZigzagCoV 0.199121
timePerZigzagSlope 0.0324689
meanError 2.47685
tremorFreq 6.73828
tremorRelPower 21.1284
tremorGyroAmpMean 0.017863
tremorGyroAmpSlope 0.0023202
tremorGyroAmpCoV 0.321536
tremorCoordAmpMean 0.245522
tremorCoordAmpSlope -0.00466234
tremorCoordAmpCoV 0.639801
tremorAccAmpMean 0.0343938
tremorAccAmpSlope -0.000201713
tremorAccAmpCoV 0.40585
tremorPcRelVar 0.835162
tremorPcX 0.0106671
tremorPcY -0.999943

ZigZag Segment 1

Duration 29.48 s, Accuracy Estimate 2.906 (lower is better)

ZigZag Segment 2

Duration 22.92 s, Accuracy Estimate 2.917 (lower is better)

ZigZag Segment 3

Duration 19.04 s, Accuracy Estimate 2.547 (lower is better)

ZigZag Segment 4

Duration 22.36 s, Accuracy Estimate 1.656 (lower is better)

ZigZag Segment 5

Duration 25.84 s, Accuracy Estimate 2.47 (lower is better)

ZigZag Segment 6

Duration 32.84 s, Accuracy Estimate 2.365 (lower is better)

ZigZag Offset

numZigzags 6
timePerZigzagMean 25.9333
timePerZigzagCoV 0.256278
timePerZigzagSlope -0.115549
zigzagHeightMean 52.2053
zigzagHeightCoV 0.10199
zigzagHeightSlope -0.0275583
meanError 0.0784191
tremorFreq 5.66406
tremorRelPower 24.8903
tremorGyroAmpMean 0.0289277
tremorGyroAmpSlope 0.00136571
tremorGyroAmpCoV 0.384884
tremorCoordAmpMean 0.206422
tremorCoordAmpSlope 0.00174441
tremorCoordAmpCoV 0.760343
tremorAccAmpMean 0.0965368
tremorAccAmpSlope 0.00142513
tremorAccAmpCoV 0.149123
tremorPcRelVar 0.799079
tremorPcX 0.0500822
tremorPcY 0.998745

ZigZag Offset Segment 1

Duration 34.48 s, Accuracy Estimate 0.055 (lower is better)

ZigZag Offset Segment 2

Duration 27.44 s, Accuracy Estimate 0.054 (lower is better)

ZigZag Offset Segment 3

Duration 30.28 s, Accuracy Estimate 0.115 (lower is better)

ZigZag Offset Segment 4

Duration 20.92 s, Accuracy Estimate 0.1 (lower is better)

ZigZag Offset Segment 5

Duration 26.6 s, Accuracy Estimate 0.041 (lower is better)

ZigZag Offset Segment 6

Duration 15.88 s, Accuracy Estimate 0.104 (lower is better)

Appendices

Misc

Currently a dumping ground for things that could be included or previous output style.

Note

Putting all the results out here but will not be in a final report.

HiSpec {‘HiSpec_class’: ‘NOT PD’, ‘HiSpec_score’: 0.8}
RanFor {‘RanFor_class’: ‘PD’, ‘RanFor_score’: 0.62}
BM_May22 {‘BM_May22_class’: ‘PD’, ‘BM_May22_score’: 0.9906731740451216}
BM_HC_Sep22 {‘BM_HC_Sep22_class’: ‘Patient’, ‘BM_HC_Sep22_score’: 0.8889925139422921}
BM_PD_Sep22 {‘BM_PD_Sep22_class’: ‘PD’, ‘BM_PD_Sep22_score’: 0.8015260902824735}